Description

Role duties and description:
-Develop extraction protocols and targeted LCMS methods for quantitation of small molecules such as drug metabolites, hormones, vitamins, etc. from biological fluid matrices such as urine, serum,
and saliva.
-Design and conduct experiments to perform validation studies of newly developed LCMS/HPLC methods.
-Evaluate performance of developed LCMS methods through data analysis using software such as Analyst, Mulitquant, Excel, etc.
-Operate, maintain, troubleshoot, and occasionally repair Sciex QQQ LCMS instrumentation, HPLC, and Tecan liquid handlers. Regularly assess the status of LCMS instrumentation to get ahead of potential failures and issues.
-Program Tecan liquid handlers to scale up clinical sample preparation.
-Coordinate with & provide assistance to laboratory personnel to ensure smooth operation of production-level LCMS tests, providing technical solutions to issues as they arise.
-Write reports and SOPs to clearly convey the results of experiments/validation studies and to document newly developed methods.
-Oversee communication & interaction with vendor FSE's as necessary to ensure timely maintenance and repair of instrumentation.
-Provide expert consultation on internal and external projects as required by the company.

Required qualifications:
-Candidate must be an organized self-starter, willing to work on a variety of projects, able to pivot to new areas as dictated by the company, and able to independently guide projects with minimal input.
-Education: Ph.D. in Analytical Chemistry or equivalent. M.S. or B.S. with combination of experience considered equivalent.
-Significant LCMS experience is a must, including LCMS operation, sample preparation, instrument method development, and basic to intermediate troubleshooting and maintenance. Small molecule experience is preferred, but peptide/protein/oligo/other molecule classes are considered equivalent experience.
-Experience with standard sample extraction techniques such as SPE, LLE, SLE, etc.
-LCMS data analysis experience with vendor-specific and/or vendor-agnostic software.
-Experience in HPLC-UV/vis separations of small molecules or similar.
-Excellent writing and communication skills.
-Track record of collaboration with others on larger projects.

Requirements

-Familiarity with GMP/GLP laboratory requirements, particularly in small-molecule HPLC method development and validation.
-Experience with LCMS method validation, preferably in a CAP/CLIA regulated environment.
-Familiarity with Agilent HPLCs and Sciex QQQ LCMS instrumentation, including hardware and software.
-Liquid handler experience including scripting, maintenance, and troubleshooting (Tecan or equivalent).
-Basic understanding of protein microarray process and methodology.